Determination of Ivabradine by Linear Sweep, Square Wave and Differential Pulse Voltammetric Methods Using Platinum Electrode in Pharmaceutical Preparation

Objectives: In this study, simple, fast and reliable cyclic voltammetry (CV), linear sweep voltammetry (LSV), square wave voltammetry (SWV) and differential pulse voltammetry (DPV) methods were developed and validated for determination of ivabradine in pharmaceutical preparations. Methods: The proposed methods were based on electrochemical oxidation of ivabradine at platinum electrode in acetonitrile solution containing 0.1 M LiCIO4.The well-defined oxidation peak was observed at 1.34 V. Results: The calibration curves were linear for ivabradine at the concentration range of 5-40 µg/mL for LSV, SWV and DPV methods, respectively. Intra- and inter-day precision values for ivabradine were less than 3.12, and accuracy (relative error) was better than 4.78%. The limits of detection values ranged from 1.20 to 1.60 µg/mL and quantification from 3.60 to 4.80 µg/mL. The mean recovery of ivabradine was 99.9% for pharmaceutical preparation. No interference was found from tablet excipients at the selected assay conditions. Conclusion: Developed methods in this study are accurate, precise and can be easily applied to Coralan tablet as pharmaceutical preparation.